Nick defeats General Hemlock and stops the firebombing. Reunited with Chuck among new allies, Isabela boards the plane constructed by Nick and his crew to escape Los Perdidos before the firebombing commences. She provides as much help as she can and shows how Nick does, in fact, possess the cure to the zombie outbreak inside him, making him the one orphan out of Carlito's group that would be a safeguard. Isabela returns in the third game, set ten years later, where it turns out that the protagonist Nick Ramos was, in fact, one of the orphans in Carlito's plot.
She tries her best to help Frank and Chuck Greene, but is captured and has her research destroyed by Harjit Singh before she can get to them.
It is revealed that Isabela survived the events of Dead Rising and is now a researcher working on behalf of Phenotrans under the control of Marian Mallon. Her ultimate fate is initially unknown, as she is last seen in the game kicking at zombies after she and Frank defeated Brock Mason. From that point on, Isabela aids Frank in stopping her brother's plot and helps develop a medicine that stalls his zombification following a bite from one that attacked him on the helipad. It is revealed that Carlito has done it since he is outraged by the meeting. However, she returns with a gunshot wound to her shoulder. Isabela introduces herself to Frank and promises to bring Carlito for interrogation. She reveals that the zombies are created by the Americans, not her and Carlito. When Frank next encounters Isabela, she attacks him while riding a motorcycle, but he defeats her. Frank saves her, but she runs away, accusing him of being responsible for ruining Santa Cabeza, the hometown she lives.
Later, he saw her again being held hostage by Steven Chapman, the manager of a supermarket. He tries to approach her, but a man stops him, saying this is no time to be ogling at the ladies.
Isabela is first seen in the entrance of Willamette Mall where Frank is looking at her.
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